Troponin-I (Tn-I) is one of three subunits that form the troponin complex of the thin filaments of striated muscle. The troponin complex serves as a calcium-sensitive switch that regulates striated muscle contraction. Tn-I binds actin and inhibits actomyosin ATPase activity in the absence of calcium. Cardiac Tn-I is characterized by a molecular weight of ~24 kDa. It is expresssed only in the heart and has proved to be a specific biomarker for heart disease. Cardiac Tn-I is purified by ion-exchange chromatography in conjunction with calcium dependent affinity chromatography on Troponin-C agarose.
HAZARD TESTING & WARNINGS:
Blood samples from tissue donors used in the manufacture of this product tested negative for HBsAg, Anti-HIV-1/2, HIV-1 Ag, HCV Ab, HCV Ag, & RPR/STS by FDA approved methods.
CAUTION: NO TEST CAN GUARANTEE A PRODUCT TO BE NON-INFECTIOUS. THEREFORE, ALL MATERIAL DERIVED FROM HUMAN FLUIDS OR TISSUES SHOULD BE CONSIDERED AS POTENTIALLY INFECTIOUS.
Use Statement: For Research, Remanufacturing, or Immunization use for products not subject to license under PHS Act Section 351 only.