Troponin-I is one of three subunits that form the troponin complex of the thin filaments of striated muscle. The troponin complex serves as a calcium-sensitive switch that regulates striated muscle contraction. Troponin-I binds actin and inhibits actomyosin ATPase activity in the abscence of calcium. Skeletal muscle Troponin-I exists in two isoforms, TnI-fast and TnI-slow, expressed respectively in fast- and slow-twitch muscle fibers. The two isoforms are characterized by molecular weights ~21 kDa (fast) and ~22 kDa (slow). The ratios of slow and fast isoforms vary with muscle source and species. Skeletal muscle Tn-I offered by TriChem Resources is a mixture of slow and fast isoforms. It is purified by ion-exchange chromatography in conjunction with calcium dependent affinity chromatography on Troponin-C agarose.
HAZARD TESTING & WARNINGS:
Blood samples from tissue donors used in the manufacture of this product tested negative for HBsAg, Anti-HIV-1/HIV-2, & anti-HCV by FDA approved methods.
NO TEST CAN GUARANTEE A PRODUCT TO BE NON-INFECTIOUS. THEREFORE, ALL MATERIAL DERIVED FROM HUMAN FLUIDS OR TISSUES SHOULD BE CONSIDERED AS POTENTIALLY INFECTIOUS.
Use Statement: For Research, Remanufacturing, or Immunization use for products not subject to license under PHS Act Section 351 only.