Troponin-I (Tn-I) is one of three subunits that form the troponin complex of the thin filaments of striated muscle.  The troponin complex serves as a calcium-sensitive switch that regulates striated muscle contraction.  Tn-I binds actin and inhibits actomyosin ATPase activity in the absence of calcium.  Cardiac Tn-I is characterized by a molecular weight of ~24 kDa.  It is expresssed only in the heart and has proved to be a specific biomarker for cardiac muscle damage.  Cardiac Tn-I is purified by ion-exchange chromatography in conjunction with calcium dependent affinity chromatography on Troponin-C agarose.

HAZARD TESTING & WARNINGS:

N/A

Use Statement: For use in Research or Remanufacture of non-injectable products not subject to license under PHS Act Section 351 only.